NMN
NMN: Refuel Your Cells for Healthy Aging
Every cell in your body relies on a vital coenzyme called NAD+ (nicotinamide adenine dinucleotide) [1]. Think of NAD+ as the essential fuel for your cellular "power plants" (the mitochondria) that manage your body's energy and upkeep.
As we age, our natural NAD+ levels significantly decline. This decline is considered a key factor in the aging process.
NMN (Nicotinamide Mononucleotide) is a direct precursor to NAD+. This means it provides the raw material your body needs to boost and restore its NAD+ levels [1, 2]. By replenishing this critical coenzyme, NMN supplementation supports cellular energy and vitality, helping you combat fatigue.
Furthermore, NAD+ is essential for activating sirtuins, often called "longevity genes." These sirtuins play a crucial role in DNA repair and overall cellular health, helping your cells function more effectively as you get older [1]. Human clinical trials have demonstrated that NMN supplementation is safe, well-tolerated, and effective at increasing NAD+ levels in the body [4, 5].
While the science of NMN is rapidly advancing, it is important to note that many human trials are still in their early stages. The full long-term effects are still being investigated, and individual results can always vary.
1. Yoshino, J., J.A. Baur, and S.-i. Imai, NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metabolism, 2018. 27(3): p. 513-528.
2. Benjamin, C. and R. Crews, Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications. Metabolites, 2024. 14(6): p. 341.
3. Mills, K.F., et al., Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab, 2016. 24(6): p. 795-806.
4. Igarashi, M., et al., Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. NPJ Aging, 2022. 8(1): p. 5.
5. Yi, L., et al., The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience, 2023. 45(1): p. 29-43.